Certain Death

If the creature becomes an illegal target for Certain Death, no player gains or loses life. If it’s a legal target but isn’t destroyed, most likely due to having indestructible, its controller still loses 2 life and you gain 2 life.

The targeted creature will have already left the battlefield before its controller loses 2 life and you gain 2 life. If it has any abilities that care about gaining or losing life, they won’t apply.